Research programs required to understand the genetic basis of drug-induced SAEs." Other prominent research collaborations focusing on biomarker development and qualification announced over the course of 2006 include: The Oncology Biomarkers Qualification Initiative: A collaboration between FDA, CMS and the National Cancer Institute focusing on imaging, molecular diagnostic assays and targeted therapies, clinical trials and data mining. The first projects will evaluate FDG-PET imaging in non-Hodgkin's lymphoma and non-small cell carcinoma "The Pink Sheet" Feb. 20, 2006, p. 3 ; . The Biomarkers Consortium: A public-private consortium including FDA, NIH, PhRMA and BIO. In addition to OBQI research, the consortium will be involved in identifying biomarkers for treatment response in major depressive disorder, evaluating adiponectin as a predictive biomarker for glycemic efficacy and a diabetes and pre-diabetes biomarker project "The Pink Sheet" Oct. 9, 2006, p. 3 ; . Predictive Safety Testing Consortium: A collaboration between the Critical Path Institute and 15 pharma companies that share data about drug-induced nephrotoxicity, hepatotoxicity, vascular injury and carcinogenicity to crossvalidate preclinical toxicity biomarkers "The Pink Sheet" March 20, 2006, p. 8.
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The American Diabetes Association recently revised dietary guidelines. The guidelines include an alternative approach -- replacing saturated fat with cis-monounsaturated fat eg, olive oil as opposed to trans-fat in hydrogenated margarines ; . This is similar to the Mediterranean diet. They also recommended a moderate increase in intake of dietary fiber to 20 to daily because of the cholesterol-lowering effects of soluble fiber. However, the effects of dietary fiber on glycemic control were considered inconsequential. They also considered it difficult to achieve a high dietary intake of soluble fiber without consuming foods or supplements fortified with fiber. This study assessed the effect of increasing intake of dietary fiber on glycemic control and lipid profiles exclusively through the consumption of foods not fortified with fiber but containing more fiber than the ADA recommends. Conclusion: The high dietary fiber diet improved glycemic control and the lipid profile. STUDY 1. Randomized, cross-over study entered 13 patients with type 2 diabetes. 2. Randomized to: 1 ; diet containing moderate amounts of fiber total 24 g -- 8 soluble, 16 g insoluble ; content. 3 The high fiber diet contained unfortified foods with naturally higher fiber content: cantaloupe, grapefruit, orange, papaya, raisins, lima beans, okra, sweet potato, winter squash, zucchini, granola, oat bran and oatmeal. No fiber supplements were used. 4. Diets were consumed for 6 weeks. Subjects were then crossed-over to the other diet for another 6 weeks. RESULTS 1. Mean outcomes at 6 weeks-- high fiber diet vs the ADA diet: Total cholesterol Triglycerides VLDL cholesterol LDL- cholesterol HDL-cholesterol DISCUSSION 1. The intake of fiber in the Western populations is low, averaging 17 g in the U.S. It is feasible to increase a high intake of soluble fiber by consuming unfortified foods. Subjects accepted the diet well. It had few side effects. The investigators believe that such diets are more palatable than diets fortified by fiber preparations and supplements. 2. In this study, the diets were comparable in caloric and nutrient content. Only the fiber -14% -21% -5% -9% -1% as recommended by the ADA, or 2 ; a high fiber diet total 50 g -- 25 soluble, 25 g insoluble ; . Diets were prepared in a research kitchen and contained the same macronutrient and energy.
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Boehringer Ingelheim is a pharmaceutical company that generates almost 80 % of its net sales with prescription medicines. Yet we do not measure our success in financial key figures alone, but also, and of equal importance, in terms of the acceptance of our products and programmes. For instance, in conjunction with our donation programme for the anti-AIDS product viramune, we have so far succeeded in providing medication for almost 1 million mother-child pairs in around 60 countries for the prevention of mother-to-child transmission of HIV. About six million patients benefited from our product spiriva for chronic obstructive pulmonary disease COPD ; . The number of patients using our anti-hypertension medicine micardis amounted to more than four million in 2006 and nicotine.
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Health news health videos opinions forum contact boehringer ingelheim provides key background on nevirapine main category: hiv aids news article date: 17 dec 2004 - pdt email to a friend printer friendly view write opinions rate article newsletters visitor ratings: healthcare professional: general public: rate this article in light of recent interest in the use of viramune nevirapine ; , boehringer ingelheim bi ; provides the following background information on the drug and key events that have been revisited by the media and nortriptyline.
S107-05 S107-02 Imaging motivation John Francis William Deakin, Neuroscience Psychiatry Unit, 6907 Stopford Bldg, Oxford Rd., Manchester M13 9PT, United Kingdom, Email: bdeakin fs1 g.man.ac R. Elliott, M. Dolan, I.M. Anderson, S.R. Williams, N. Horn, B. Kulkhani Objective: Depression, drug abuse and antisocial behaviour can be seen as disorders of motivational mechanisms. We are developing functional magnetic resonance imaging fMRI ; to visualise brain mechanisms of reward and behavioural inhibition, and their modulation by 5HT in volunteers and patient groups. Methods: 1.5T Philips MR. Block design gambling & go no-go paradigms. Statistical Parametric Mapping of the brain comparing reward vs rest; nogo vs go blocks. Direct effect of iv m-chloro-phenylpiperazine 5HT2C agonist ; and its modulation of the no-go effect, compared with placebo in 8 volunteers. Results: Our present and previous results show that winnings activate dopaminergic regions, including ventral tegmental area and ventral striatum Elliott, 2000 ; and medial orbito-frontal cortex. Inhibition of responses in nogo blocks was associated with lateral orbito-frontal cortex activation. mCPP caused focal activation in hypothalamic and ventral striatal regions and it potentiated frontal activation by no-go blocks. Conclusions: Dopamine & medial orbito-frontal cortex involved in reward in humans, and, 5HT & lateral orbito-frontal cortex with behavioural inhibition. mCPP activation strikingly parallels distribution of 5HT2C receptors. References: Deakin JFW 1996 ; : 5HT, antidepressant drugs and the psychosocial origins of depression, Journal of Psychopharmacology 10 1 ; : 31-38 Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ 2000 ; : Selective attention to emotional stimuli in a verbal go no-go task: an fMRI study, NeuroReport 11: 1739-1744.
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That CGRP inhibits NF-B activity, which participates in the IL-1-induced chemokine expression. Adrenomedullin is a 52-amino acid peptide with structural homology to CGRP. However, our data showed that it did not significantly inhibit IL-1-induced chemokine secretion data not shown ; , which indicates that the two peptides have different functions. In addition, hCGRP8-37 failed to show a dose-dependent elevation in IL-1-induced IL-8 and MCP-1 secretion, possibly because the peptide antagonist derived from part of the overall peptide may act as an agonist, especially at high concentrations. For this reason, we recently used the RNAi technique to "knock out" the -CGRP gene in A549 cells. The initial result from a few clones showed that the basal and IL-1-induced IL-8 and MCP-1 secretion in these clones was significantly magnified data not shown ; . In summary, IL-1 induced CGRP secretion via the PKC-p38-MAPK-NF-B pathway in human A549 AEII cells. And by using the CGRP-1 receptor antagonist hCGRP8-37 and exogenous agonist hCGRP, the cAMP-PK inhibitor, we also showed that AEII cell-derived -CGRP could suppress inflammatory chemokine IL-8 and MCP-1 secretion induced by IL-1 via a cAMP-PK-dependent mechanism. This study provides new insight into the immunomodulating effects of endogenous CGRP from AEII cells under pathologic lung conditions. ACKNOWLEDGMENTS This research project was supported by grants from the Major National Basic Research Program of P. R. China No. G2000056908 ; awarded to X. W. and a National Natural Science Foundation of the Peoples Republic of China, No. 30330250, awarded to X.W. REFERENCES 1. 2. 3. Springer, J., Geppetti, P., Fischer, A., and Groneberg, D. A. 2003 ; Calcitonin gene-related peptide as inflammatory mediator. Pulm. Pharmacol. Ther. 16, 121-130 Keith, I. M. 2000 ; The role of endogenous lung neuropeptides in regulation of the pulmonary circulation. Physiol. Res. 49, 519537 Xu, H., Zhao, M., and Wang, X. 1999 ; Changes of calcitonin gene-related peptide content in induced sputum from patients with COPD and asthma. Zhonghua Jie He He Hu Zhi 22, 558561 Xu, H., Zhao, M., and Wang, X. 1999 ; The levels of calcitonin gene-related peptide in pathogenesis of chronic bronchitis rats. Natl. Med. J. China 79, 385387 Chung, K. F. 2001 ; Cytokines in chronic obstructive pulmonary disease. Eur. Respir. J. Suppl. 34, 50s59s Townley, R. G., and Horiba, M. 2003 ; Airway hyperresponsiveness: a story of mice and men and cytokines. Clin. Rev. Allergy Immunol. 24, 85110 Stankiewicz, W., Dabrowski, M. P., Chcialowski, A., and Plusa, T. 2002 ; Cellular and cytokine immunoregulation in patients with chronic obstructive pulmonary disease and bronchial asthma. Mediators Inflamm. 11, 307312.
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Boehringer Ingelheim generates almost 80 % of its net sales with prescription medicines. Yet we do not measure our success in financial key figures alone, but also in terms of the acceptance of our products and programmes. In conjunction with our donation programme for the anti-AIDS product viramune, we have so far provided medication for almost one million mother-child pairs in around 60 countries for the prevention of mother-to-child transmission of HIV. About six million patients benefited from our product spiriva for chronic obstructive pulmonary disease COPD ; . The number of patients using our anti-hypertension medicine micardis amounted to more than four million in 2006.
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Neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 93: 74-104 118. Gage FH, Dunnett SB, Bjorklund A 1984 Spatial learning and motor deficits in aged rats. Neurobiol Aging 5: 43-8 119. Rapp PR, Rosenberg RA, Gallagher M 1987 An evaluation of spatial information processing in aged rats. Behav Neurosci 101: 3-12 120. Bach ME, Barad M, Son H, Zhuo M, Lu YF, Shih R, Mansuy I, Hawkins RD, Kandel ER 1999 Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc Natl Acad Sci U S A 96: 5280-5 121. Zornetzer SF, Thompson R, Rogers J 1982 Rapid forgetting in aged rats. Behav Neural Biol 36: 49-60.
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4.6.1 The Pharmaceuticals Division Provides the Majority of Net Sales in Novartis 4.6.2 Vaccines and Diagnostics Operating Loss of $26m in 2006 4.6.3 Sandoz Operating Income Increased 115% in 2006, with Landmark Approval of Omnitrope The First Biosimilar to Reach the Market 4.6.4 New Product Launches Are Vital To Novartis' Continuing Growth and Competitiveness 4.7 Since Its Inception in 1996, Novartis Has Progressively Divested Itself of NonHealthcare Business Units 4.8 Recent Mergers & Acquisitions by Novartis 4.8.1 Acquisition of Chiron in 2006 Led to Establishment of Vaccines and Diagnostics Division 4.8.2 Acquisition of Hexal and Eon Labs in 2005 Made Sandoz a World Leader in Generics 4.8.3 Strengthening of Sandoz in 2004 4.8.4 From 2002-2003 Novartis Further Expanded Its Portfolio 4.9 Novartis' International Strategy Strong Emphasis on Asian Markets, Especially China 4.9.1 US Market Contributes Most Sales 4.9.2 Novartis Is Active in the Japanese Market 4.9.3 Novartis Has Great Deal of Optimism For Growth in China 4.9.4 India is Another Developing Market Prioritised by Novartis 4.10 Novartis Uses Research Alliances Extensively 4.11 Novartis Due to Establish a Strategic Biomedical R&D Centre in Shanghai, China 5 Novartis Consumer Health 5.1 Consumer Health Division Established in 1998 5.2 Solid Results for Consumer Health in 2006 5.3 Steady Growth Expected from 2007-2012 in Consumer Health 5.4 Novartis Sold its Medical Nutrition Business in 2006 6 Novartis Vaccines and Diagnostics 6.1 Novartis Vaccines and Diagnostics is a New Division of Novartis 6.2 Operating Loss of $26m in 2006 for Vaccines and Diagnostics 6.3 Sales Will Increase Strongly As Vaccines and Diagnostics Division Becomes Established in The Novartis Group 6.4 Portfolio Benefits from Increased Strategic Focus 6.5 US Government Contract to Develop Novel Antigen Technology to Increase Vaccine Supplies for Pandemics 6.5.1 Novartis Awarded US Government Contract to Supply Vaccine Against H5N1 Avian Influenza 6.6 Novartis Making Significant Progress In Creating New Strategic Growth Platform In Human Vaccines 6.6.1 Production of H5N1 Influenza Vaccine for Other Countries 6.6.2 Cell Culture-Based Influenza Vaccines Promise Many Advantages 7 Novartis' Sandoz Generics Division 7.1 Background: Novartis Re-branded Its Generics Companies as Sandoz 7.2 Sandoz Has A Complex History From Establishment in 1886 to Present 7.3 Sandoz Has a Broad Product Range, Much of it Due to Acquisition of Generics and nicotine.
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ILLINOIS REGISTER DEPARTMENT OF PUBLIC HEALTH DRAFT NOTICE OF ADOPTED AMENDMENTS of their responsibilities in accordance with the Sexual Assault Survivors Emergency Treatment Code Rules and Regulations 77 Ill. Adm. Code 545 ; and the Sexual Assault Survivors Emergency Treatment Act [410 ILCS 70] Ill. Rev. State. 1987, ch. 111 , par. 87-1 et seq., as amended by Public Act 85-577, effective September 18, 1987 ; . 1. The hospital Hospital shall provide an appropriate medical screening examination and initial stabilizing treatment. emergency services if the alleged sexual assault survivor requires initial resuscitation or other emergency care so that the survivor can be safely transported to another hospital. Only those injuries should be treated that the physician deems medically unsafe to postpone until transfer to another facility. See Section 545.65 a ; of the Regulations. ; . The hospitalHospital shall provide pre-transfer and transfer services to alleged sexual assault survivors in accordance with Section 545.65 a ; of the Rules and Regulations. The hospitalHospital shall provide such services at no direct charge to the patient. If the patient is neither eligible to receive such services under the Illinois Public Aid Code nor is covered by a policy of insurance, the Hospital hospital shall seek reimbursement only from the Department of Public Aid IDPA ; . The hospital shall comply with the Emergency Medical Treatment Act [210 ILCS 70] and the federal Emergency Medical Treatment and Active Labor Act 42 USC 1395dd ; . The hospital Hospital shall submit billings to IDPA the Department on properly authenticated vouchers supplied by IDPA the Department for all eligible patients for whom hospital emergency services were provided pursuant to its Transfer Plan. The hospital Hospital shall maintain all patient medical records, accounting records, or other evidence pertaining to the cost incurred and make such materials available for three 3 ; years or until completion of any outstanding audit. in a manner and for a duration established by hospital policy and for not less than 10 years, in accordance with Section 6.17 of the Hospital Licensing Act. The hospital shall maintain all business and professional records in accordance with acceptable business and accounting practices, and all records shall be legible. Records shall be retained for a period of not less than three years after the date of service or as required by State law, whichever period is longer, except that if an audit is initiated within the required retention period, the records shall be retained until the audit is completed and every exception is resolved. FOR THE HOSPITAL: Administrator Source: Amended at 26 Ill. Reg. , effective.
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Ing modality that is becoming more com monplace. In breast MRI, the patient is injected with an MRI contrast agent typi cally gadolinium and undergoes a MRI imaging sequence. Both methods look for local contrast agent concentrations that might indicate breast cancer, both look for washin and washout characteristics to dif ferentiate benign from malignant patholo gies, and both image the contrast agents using 3D technology. Clinical Applications Contrastenhanced breast tomosynthe sis is being investigated for use in several clinical areas, including the differentiation of normal tissue from cancerous tissue. Often clinicians can't make a diagnosis on the basis of tissue appearance because benign and malignant structures can look identical mammographically. However, a rapidly growing malignant cancer could be expected to have increased blood flow and, therefore, increased contrast agent uptake in its vicinity. Another potential use of contrast en hanced breast tomosynthesis is in the identification of secondary cancers follow ing diagnosis of a primary cancer site. This helps guide appropriate treatment, deter mining whether a lumpectomy or mastec tomy is the appropriate course of action. Yet another possible benefit involves monitoring cancer therapy, such as tracking tumor size during chemo therapy regimens. These are all ar eas where breast MRI has shown promise. Contrastenhanced breast tomosynthesis might offer similar clinical value at reduced cost and greater availability than an expen sive MRI procedure. Digital's Influence Many exciting new technologies are be ing applied to breast cancer Detection all of them are designed to address the accuracy limita tions of conventional screenfilm mammo graphy. While digital mammography has of fered many advantages in image quality and productiv ity, its real advantage is thought be as an enabling technology. It has prompted huge improvements in com puteraided detection, contrastenhanced mammography and 3D tomosynthesis. Contrastenhanced breast tomosynthesis is the latest advance in that progression to better breast health.
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