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We thank Dr. Hong Du for constructive suggestions and help in animal techniques. We thank Drs. Jeffrey A. Whitsett and Jay Tichelaar for discussions and providing CCSP-rtTA and SP-C rtTA transgenic mice and the pUHD tetO ; 7CMV plasmid originally from Dr. H. Bujard ; . We thank Dr. Susan Wert for helping morphometrical measurements. We thank Dr. P. Chambon for providing the human RAR expression vector and Dr. R. DeLauro for providing the TTF-1 antibody. Received December 9, 2002. Accepted March 7, 2003. Address all correspondence and requests for reprints to: Cong Yan, Ph.D., Children's Hospital Medical Center, Division of Pulmonary Biology, The Children's Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039. E-mail: Cong.Yan chmcc . This work was supported by NIH Grant HL-61803 to C.Y. ; and March of Dimes Grant FY02-206 to C.Y and orlistat.
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Section 1301.10 All Races Governed by Rules and Regulations All races shall be conducted only under the Rules and Regulations of the Illinois Racing Board. Section 1301.20 Situations not Provided for in the Rules Any situation not covered by the rules of this Board shall be referred to the Board for disposition. Section 1301.50 Full Access to Track The Board, its secretary, representatives, officials and employees shall at all times have full access to the course, plant and grounds, including the judges' stand and the pari-mutuel department. Section 1301.60 Inspection of Horsemen's Tack The Board or the state steward shall have the right to authorize a person or persons to enter any place within the track enclosure or other places where horses are kept that are eligible to race at the current meetings to inspect and examine the personal effects, or property within such places of every trainer, driver, stable foreman, groom, attendant, authorized agent and veterinarian, or any of them. SOURCE: Published in Rules and Regulations of Harness Racing, original date not cited in publication added January 10, 1975, filed January 16, 1975; codified at 5 Ill. Reg. 10918; Section 1301.80 recodified to 11 Ill. Adm. Code 207.40 at 9 Ill. Reg. 11652; Repealed effective November 1, 2001 and parlodel.
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Vs. the same chemotherapy alone. Among these patients, 54% had node positive disease and 46% had node negative disease. Among women with ER positive or unknown breast cancer and positive nodes who received about 5 years of treatment, overall survival at 10 years was 61.4% for NOLVADEX vs. 50.5% for control logrank 2p 0.00001 ; . The recurrence-free rate at 10 years was 59.7% for NOLVADEX vs. 44.5% for control logrank 2p 0.00001 ; . Among women with ER positive or unknown breast cancer and negative nodes who received about 5 years of treatment, overall survival at 10 years was 78.9% for NOLVADEX vs. 73.3% for control logrank 2p 0.00001 ; . The recurrence-free rate at 10 years was 79.2% for NOLVADEX versus 64.3% for control logrank 2p 0.00001 ; . The effect of the scheduled duration of tamoxifen may be described as follows. In women with ER positive or unknown breast cancer receiving 1 year or less, 2 years or about 5 years of NOLVADEX, the proportional reductions in mortality were 12%, 17% and 26%, respectively trend significant at 2p 0.003 ; . The corresponding reductions in breast cancer recurrence were 21%, 29% and 47% trend significant at 2p 0.00001 ; . Benefit is less clear for women with ER poor breast cancer in whom the proportional reduction in recurrence was 10% 2p 0.007 ; for all durations taken together, or 9% 2p 0.02 ; if contralateral breast cancers are excluded. The corresponding reduction in mortality was 6% NS ; . The effects of about 5 years of NOLVADEX on recurrence and mortality were similar regardless of age and concurrent chemotherapy. There was no indication that doses greater than 20 mg per day were more effective. Node Positive - Individual Studies - Two studies Hubay and NSABP B-09 ; demonstrated an improved disease-free survival following radical or modified radical mastectomy in postmenopausal women or women 50 years of age or older with surgically curable breast cancer with positive axillary nodes when NOLVADEX was added to adjuvant cytotoxic chemotherapy. In the Hubay study, NOLVADEX was added to "lowdose" CMF cyclophosphamide, methotrexate and fluorouracil ; . In the NSABP B-09 study, NOLVADEX was added to melphalan [L-phenylalanine mustard P ; ] and fluorouracil F ; . In the Hubay study, patients with a positive more than 3 fmol ; estrogen receptor were more likely to benefit. In the NSABP B-09 study in women age 50-59 years, only women with both estrogen and progesterone receptor levels 10 fmol or greater clearly benefited, while there was a nonstatistically significant trend toward adverse effect in women with both estrogen and progesterone receptor levels less than 10 fmol. In women age 60-70 years, there was a trend toward a beneficial effect of NOLVADEX without any clear relationship to estrogen or progesterone receptor status. Three prospective studies ECOG-1178, Toronto, NATO ; using NOLVADEX adjuvantly as a single agent demonstrated an improved disease-free survival following total and pletal.
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Women's experience and satisfaction with emergency contraception. Fam Plann Perspect 1999 Sep-Oct; 31 5 ; : 237-40, 260 Harvey SM, Beckman LJ, Sherman C, Petitti D Pacific Institute for Women's Health, Los Angeles, CA, USA. CONTEXT: If any new contraceptive technology is to become a viable option for decreasing unintended pregnancies, women must be willing to use the method and find it acceptable. However, because emergency contraceptive pills have not been widely used, very little is known about this method's acceptability. METHODS: Telephone interviews were conducted with 235 women who had received emergency contraceptive pills through a demonstration project at 13 Kaiser Permanente medical offices in San Diego to assess women's experience and satisfaction with the pills. RESULTS: More than two-thirds of the women 70% ; were using a contraceptive method prior to their need for emergency contraception, and 73% of these users were relying on condoms. When asked about the situation that led to unprotected intercourse, 45% reported that their condom broke or slipped, while 23% said they had had unplanned sex. More than three-quarters of the sample 81% ; experienced at least one side effect. The overwhelming majority were satisfied with emergency contraceptive pills 91% ; and would recommend them to friends and family members 97% ; . Just one-quarter of the sample 28% ; believed that emergency contraceptive pills should be dispensed over the counter, and an even lower proportion agreed that they should be available from vending machines 6% ; . CONCLUSIONS: Because women were overwhelmingly accepting of emergency contraceptive pills, found them easy to use and did not intend to substitute them for regular contraceptive use, this new method is an important addition to the contraceptive options available to women, providing a way to prevent pregnancy after unprotected intercourse or method failure.
Diac surgery with cardiopulmonary bypass. Pediatr Crit Care Med 2004; 5: 246 Egan JR, Lammi A, Schell DN, Gillis J, Nunn GR. Recombinant activated factor VII in paediatric cardiac surgery. Intens Care Med 2004; 30: 6825. Stratmann G, Russell IA, Merrick SH. Use of recombinant factor VIIa as a rescue treatment for intractable bleeding following repeat aortic arch repair. Ann Thorac Surg 2003; 76: 2094 Al Douri M, Shafi T, Al Khudairi D, et al. Effect of the administration of recombinant activated factor VII rFVIIa; NovoSeven ; in the management of severe uncontrolled bleeding in patients undergoing heart valve replacement surgery. Blood Coagul Fibrinolysis 2000; 11 Suppl 1 ; : 1217. Herbertson M. Recombinant activated factor VII in cardiac surgery. Blood Coagul Fibrinolysis 2004; 15 Suppl 1 ; : 312. Dietrich W, Spannagl M. Caveat against the use of activated recombinant factor VII for intractable bleeding in cardiac surgery. Anesth Analg 2002; 94: 1369 [author reply 1370-1]. von Heymann C, Ziemer S, Kox WJ, Spies C. Caveat against the use of feiba in combination with recombinant factor VIIa. J Thorac Cardiovasc Surg 2003; 126: 1667 Despotis G, Avidan M, Lublin DM. Off-label use of recombinant factor VIIA concentrates after cardiac surgery. Ann Thorac Surg 2005; 80: 35. Goodnough LT. Experiences with recombinant human factor VIIa in patients with thrombocytopenia. Semin Hematol 2004; 41 Suppl 1 ; : 259. Ilabaca PA, Ochsner JL, Mills NL. Positive end-expiratory pressure in the management of the patient with a postoperative bleeding heart. Ann Thorac Surg 1980; 30: 281 Hoffman WS, Tomasello DN, MacVaugh H. Control of postcardiotomy bleeding with PEEP. Ann Thorac Surg 1982; 34: 713. Murphy DA, Finlayson DC, Craver JM, et al. Effect of positive end-expiratory pressure on excessive mediastinal bleeding after cardiac operations. A controlled study. J Thorac Cardiovasc Surg 1983; 85: 864 Zurick AM, Urzua J, Ghattas M, Cosgrove DM, Estafanous FG, Greenstreet R. Failure of positive end-expiratory pressure to decrease postoperative bleeding after cardiac surgery. Ann Thorac Surg 1982; 34: 608 Collier B, Kolff J, Devineni R, Gonzalez LS III. Prophylactic positive end-expiratory pressure and reduction of postoperative blood loss in open-heart surgery. Ann Thorac Surg 2002; 74: 1191 DeBois W, Krieger KH. The influence of oxygenator type and priming volume on blood requirements. In: Krieger KH, Isom OW, eds. Blood conservation in cardiac surgery. New York: Springer, 1998: 32754. Liddicoat JE, Bekassy SM, Beall AC Jr, Glaeser DH, DeBakey ME. Membrane versus bubble oxygenator: clinical comparison. Ann Surg 1975; 181: 74753. Clark RE, Beauchamp RA, Magrath RA, Brooks JD, Ferguson TB, Weldon CS. Comparison of bubble and membrane oxygenators in short and long perfusions. J Thorac Cardiovasc Surg 1979; 78: 655 Hicks GL, Zwart HH, DeWall RA. Membrane versus bubble oxygenators: a prospective study of 52 patients. Arch Surg 1979; 114: 12857. Hessel EA II, Johnson DD, Ivey TD, Miller DW Jr. Membrane versus bubble oxygenator for cardiac operations. A prospective randomized study. J Thorac Cardiovasc Surg 1980; 80: 11122. Sade RM, Bartles DM, Dearing JP, Campbell LJ, Loadholt CB. A prospective randomized study of membrane versus bubble oxygenators in children. Ann Thorac Surg 1980; 29: 50211. Huber R, Mennicke C, Heitmann KU, Helling HJ, Huber PM. Membrane versus bubble oxygenator in hyperthermic regional perfusion: a prospective randomized clinical study. Eur Surg Res 1994; 26: 210!
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