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1 Agreus L. Natural history of dyspepsia. Gut 2002; 50 Suppl 4: iv2-iv9. 2 Westbrook JI, Duggan AE, Duggan JM, Westbrook MT. A 9 year prospective cohort study of endoscoped patients with upper gastrointestinal symptoms. Eur J Epidemiol 2005; 20: 619-627. Calam J. Clinician's guide to Helicobacter pylori. London: Chapman and Hall Medical, 1996. 4 Talley N. American Gastroenterological Association medical position statement: evaluation of dyspepsia. Gastroenterology 2005; 129: 17531755. Tytgat GN. Role of endoscopy and biopsy in the work up of dyspepsia. Gut 2002; 50 Suppl 4: iv13-iv16. 6 Numans ME, Lau J, de Wit NJ, Bonis PA. Short-term treatment with proton-pump inhibitors as a diagnostic test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Intern Med 2004; 140: 518-527. Westbrook JI, McIntosh J, Talley NJ. Factors associated with consulting medical or non-medical practitioners for dyspepsia: an Australian population-based study. Aliment Pharmacol Ther 2000; 14: 1581-1588. Engel LS, Chow W-H, Vaughan TL, et al. Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst 2003; 95: 1404-1413. Forman D. Review article: oesophago-gastric adenocarcinoma -- an epidemiological perspective. Aliment Pharmacol Ther 2004; 20 Suppl 5: 55-60. 10 Schmidt N, Peitz U, Lippert H, Malfertheiner P. Missing gastric cancer in dyspepsia. Aliment Pharmacol Ther 2005; 21: 813-820. Ford AC, Qume M, Moayyedi P, et al. Helicobacter pylori "test and treat" or endoscopy for managing dyspepsia: an individual patient data metaanalysis. Gastroenterology 2005; 128: 1838-1844. Australian Institute of Health and Welfare. Interactive cancer data. Number of new cases and age-specific rates for selected cancers by year of registration, sex and 5-year age groups. : aihw.gov.au cognos cgi-bin ppdscgi ?DC Q&E Cancer cancerageratesv7 accessed Dec 2006 ; . 13 Vakil N, Moayyedi P, Fennerty MB, Talley NJ. Limited value of alarm features in the diagnosis of upper gastrointestinal malignancy: system atic review and meta-analysis. Gastroenterology 2006; 131: 390-401.
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Pharmaceutical company Sicomed will launch June 13-20 on the Romanian market the first five products of the Gerovital cosmetics range in a first stage which is thought as a test for subsequent development of the extremely popular range of products in the United States or Japan, daily Ziarul Financiar reports on June 13. The sales target for the Romanian market in 2005 for the new range of Gerovital products is of about 1.1 million dollars, accounting for 0.6 percent of the turnover for the whole year. Gerovital brand, developed in the first half of the 20th century by Ana Aslan is currently divided between several companies which have rights for pharmaceutical products. Farmec Cluj and Gerovital Cosmetics Bucharest are entitled to produce pharmaceutical products under this name, whereas Gerovital services are provided by Ana Aslan Institute in Bucharest. At present, the cosmetics range Gerovital Line includes five products for memory, articulations, eyes, heart and menopause ; and three new items are to be produced by end-year.
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Department of Endocrinology, West China Hospital of SiChuan University, ChengDu, China. Objective: To evaluate the role of bone turnover biomarkers measurements in disease of parathyroid glands. Methods: Patients of primary hypoparathyroidism n 5 ; and primary hyperparathyroidism n 9 ; were included in this study. The serum calcium, phosphorus, parathyroid hormone PTH ; levels were measured as well as serum concentration of bone turnover biomarkers. The later includes bone alkaline phosphatase BALP ; which is the bone formation marker, and tartrate-resistant acid phosphatase 5b TRAP5b ; which is the bone resorption marker. Results: The mean serum level of calcium in patients of primary hypoparathyroidism was 1.490.30 mmol L reference values 2.1-2.7 mmol L ; , and mean PTH 1.091.13pmol L reference values 1.6-6.9 pmol L ; , while average BALP content 10.882.74 g L reference values 11.4-24.6 g L ; , and TRAP5b 1.290.98 U L reference values 1.48-4.98 U L ; . In patients of primary hyperparathyroidism, the average levels of serum calcium, PTH, BALP and TRAP5b were 3.240.82 mmol L, 145.4495.68 pmol L, 83.2240.68 g L, and 7.763.89 U L, respectively Table 1 ; . That is, serum concentration of bone formation and bone resorption biomarkers were decreased markedly in patients of primary hypoparathyroidsim, and increased in patients of primary hyperparathyroidism, which were consistency with serum levels of calcium and PTH variation. Conclusions: Above mentioned two biomarkers could reflect the conditions of bone turnover in disease of parathyroid glands effectively. Further application in clinical practice would give some help in diagnosis, therapeutic efficacy follow-up and prognosis judgement of parathyroid glands disorders, while larger sample size should be included in further study.
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