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Adrenoceptors. 5-HT activates 5-HT2A and 5-HT1D and or 5-HT1B receptors to cause contraction. ACKNOWLEDGMENTS We would like to thank the Deutsche Akademisches Austausch Dienst DAAD ; for the financial support ; and Prof. JP TILLEMENT, at the department of Pharmacology of Paris XII University for the critical analyze of the manuscript. REFERENCES.
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Introduction: The diabetes type 1 presents a poorly pancreatic function defined by endogen insulin and c-peptide levels almost not detectable. The adults stem cells CD34-CD38 have the capacity to differentiate in functional cells on endocrine pancreas. Methods: Following our first experience on cell therapy for type 2 diabetes, we had use the same technique to evaluate the response on type 1 diabetes. Has been analyzed 23 patients 14 males and 9 females ; , with 15-62 years-old, and 4-27 years of disease. All the patients were under insulin therapy and presented basal blood sugar level: 1, 96 g l; HA1c 9, 11; c-peptide 0, 29 nmol l. The patients were submitted to an implant of mononuclear cells CD34 -CD38, separated from autollogos bone marrow, through the spleen artery. The patients were subjected to clinical and blood samples control during 90 days after the implant. Results: After 90 days of implant the basal blood sugar level was 1, 71g l decreased 9, 7%, p 0, 23 ; , HbA1C 8, 34 decreased 18, 45%, p 0, 07 ; , and c-peptide level 0, 45nmol l increased of 55%, p 0, 0027 ; . It was observed that the exogenous insulin took by the patient before implant decreased from 46, 7 UI day - 32 ; to 39, 9UI day - 25 ; , descent of 17%, p 0, 08. Conclusions: The implant of mononuclear CD34 CD38- stem cells ; from autollogus bone marrow can improve pancreatic function in patients with type 1 diabetes, with no therapeutic standards relation, in a safety form and tegretol.
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