By James Jenkins, Jr. U.S. Army Materiel Command AMC ; and U.S. Army Aviation and Missile Command AMCOM ; formally recognized Letterkenny Army Depot for its outstanding cost-cutting initiatives. Letterkenny won both the Fiscal Year 2004 AMC and AMCOM Value Engineering Award for the first time since 2001. This marks the sixth consecutive year Letterkenny has won the AMCOM VE Award; and the third time Letterkenny has won both awards in the same year. Major General James Pillsbury, Commander of the Aviation and Missile Command, presented Letterkenny with the AMCOM VE Award on December 1 at the Bob Jones Auditorium. Army Materiel Command informed Letterkenny on February 8 that they also won the AMC VE Award. General Benjamin Griffin presented the AMC award in a ceremony during a working lunch on March 14 while making his first visit to Letterkenny.
The Working Party was set up independently of any input or funding from the manufacturers of the DMARDs included in the guideline. Members of the working party were asked to clarify their relationship with the pharmaceutical companies. Members were asked to declare, if they, as individuals had been sponsored to attend scientific or other meetings in the past 24 months or if they had a direct financial stake in the manufacturing companies. They were also asked if their units had received funding from the manufacturers to take part in clinical trials of any of the drugs in the DMARD guidelines. None of the Working Party members had declared any conflict of interest, for example, budesonide.
Audit The Audit Committee, composed entirely of non-employee Directors, helps the Board oversee the Company's accounting and reporting practices. It recommends independent public accountants for appointment by the Board and reviews their performance; monitors the adequacy of internal accounting practices, procedures and controls; and reviews all significant changes in accounting policies. J. G. Cullen, Chairman A. G. Langbo L. F. Mullin H. B. Schacht Benefits The Benefits Committee, composed entirely of non-employee Directors, reviews the management of the various retirement, pension, health and welfare plans that cover substantially all employees of the Company's domestic operations and employees of certain international subsidiaries. The Committee also monitors the performance of the trusts in which pension funds are invested. J. G. Cooney, Chairperson M. F. Singer, Ph.D. J. W. Snow Compensation The Compensation Committee, composed entirely of non-employee Directors, reviews the compensation philosophy and policy of the non-Board Management Compensation Committee with respect to executive compensation, fringe benefits and other compensation matters. The Committee also administers the Company's stock option plans and determines the compensation of the members of the Management Compensation Committee. A. G. Langbo, Chairman J. G. Cooney J. G. Cullen J. W. Snow Finance The Finance Committee exercises the management authority of the Board during the intervals between Board meetings. R. S. Larsen, Chairman R. N. Wilson Nominating and Corporate Governance The Nominating and Corporate Governance Committee, composed entirely of non-employee Directors, is responsible for overseeing corporate governance matters, reviewing possible candidates for Board membership and recommending nominees for election. The Committee is also responsible for evaluating the function and performance of the Board and the Chief Executive Officer. Additionally, the Committee reviews the Company's management succession plans and executive resources. H. B. Schacht, Chairman G. N. Burrow, M.D. A. D. Jordan L. F. Mullin Public Policy The Public Policy Advisory Committee is composed of Board members and the Company's Vice President, Administration. It reviews the Company's policies, programs and practices on public health issues regarding the environment and the health and safety of employees, and advises and makes recommendations to the Board on such issues. J. S. Mayo, Ph.D., Chairman R. C. Deyo M. J. Folkman, M.D. A. D. Jordan Science and Technology The Science and Technology Advisory Committee is composed of Board members and the Company's Vice President, Science and Technology. It advises the Board on scientific matters that include major internal projects, interaction with academic and other outside research organizations, and the acquisition of technologies and products. G. N. Burrow, M.D., Chairman M. J. Folkman, M.D. J. S. Mayo, Ph.D. R. W. Ruddon, M.D., Ph.D. M. F. Singer, Ph.D.
Profit before tax & after Extraordinary item as per Profit & Loss Account Add: Managerial Remuneration Directors' Sitting Fees Provision for Doubtful Debts Less: Profit on Sale of Investments Profit on Sale of Fixed Assets Net Profit under Section 349 of the Companies Act, 1956 Managerial remuneration permissible maximum 20. Related Party Disclosures Related party disclosures, as required by AS-18, "Related Party Disclosures", of the Institute of Chartered Accountants of India are given below: i. There are no related parties except the following: a. Two trusts namely Cipla Public Charitable Trust and Dr. K.A. Hamied Foundation. b. Key management personnel, namely Dr. Y.K. Hamied, Mr. M.K. Hamied and Mr. Amar Lulla. ii. Donations given to Cipla Public Charitable Dr. K.A. Hamied Foundation Rs.74.00 million. iii. Refer Note 18 for details of managerial remuneration. Trust Rs.0.20 million and to 3944.41 119.97 0.36, because drug interactions.
The U.S. Government has rights in this invention arising out of the partial funding of work leading to this invention through the National Institutes of Health Grant Nos. AI-26055, AI-28731, NIH 5-21935, as well as a Veteran's Administration Merit Review Award.
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Each sleep period and immediately performed a computerized 2-minute task consisting of rapid serial additions of paired 2-digit numbers. Subjective sleepiness was also reported Karolinska Sleepiness Scale ; . Sleep inertia was quantified as the change in number of additions attempted cognitive performance ; and subjective sleepiness when tests were repeated after ~20 min. Data were analyzed only following awakenings from Stage II sleep. Core body temperature was used as a marker of circadian phase, with data binned into 60 circadian bins, normalized to account for differences between subjects Z-score ; , and Cosinor analysis was used to assess circadian rhythmicity. Results : Immediately upon awakening, subjects attempted an average of 22 additions, which improved to 26 after 20 minutes. There was a significant circadian rhythm in sleep inertia of cognitive performance P 0.001 ; , with peak improvement during the biological night circadian phase bin 300 ; , no improvement during the biological day 180 ; , and a peak to trough amplitude of ~20% 4 more additions attempted ; . Analyzing correct additions gave similar results. Average subjective sleepiness was high immediately upon awakening 7.5 on scale of 1-9 ; and fell by only 1 unit after 20 minutes. There was no significant circadian rhythm in sleep inertia of sleepiness. Conclusion : There is a clear circadian rhythm in the degree of sleep inertia of cognitive performance but no circadian rhythm in the sleep inertia of subjective sleepiness. These findings may have important implications for professions requiring decision making immediately upon awakening, e.g., on-call medical professionals. Support optional ; : NIH HL64815; NCRR GCRC M01 RR02635; Pickwick Fellowship in support of FAJLS.
View pubmed citation publication history issue online: 24 dec 2003 home list of issues table of contents article abstract dermatologic therapy volume 16 issue 4 page 283-287, december 2003 to cite this article: herschel zackheim 2003 ; treatment of patch-stage mycosis fungoides with topical corticosteroids dermatologic therapy 16 4 ; , 283– 28 doi: 1 1111 j 96-029 200 0163 x prev article next article abstract treatment of patch-stage mycosis fungoides with topical corticosteroids herschel zackheim department of dermatology, university of california, san francisco, california address correspondence and reprint requests to: herschel zackheim, department of dermatology, university of california, san francisco, 2327 branner dr and biaxin!
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Be the key factor that bridges everything risk for steatosis, risk for NASH and also risk for some of the cardiovascular complications like hypertension and coronary artery disease. If you can improve insulin sensitivity, you can potentially improve all these factors. Some of the lipid-lowering agents are very useful in decreasing the hepatic triglyceride content; they improve hypertriglyceridemia and this in turn seems to improve IR. It's kind of a cycle improve one, you improve the other. So there's a lot of interest now in lipid lowering agents as therapeutic agents for NAFLD as well. The way we're thinking about some of these drugs has really changed over the last few years. There's a lot of literature on studies trying to look at whether we can predict who is at risk for NASH and also predict more severe liver disease including fibrosis based on serological markers. People have looked at several things such as fibrosis markers, DHEA, and gene polymorphisms. Basically, the question is "Are there some target genes that, when they change, actually put someone at a higher risk of more severe liver disease?" The first abstract is on the role of DHEA dehydroepiandrosterone ; in NAFLD. DHEA is basically an adrenal steroid and there is some data to show that it is anti-diabetic and it may also improve IR and obesity. So where does DHEA come in, in terms of NASH? Abstract 224655: "Low circulating DHEA levels in severe non-alcoholic fatty liver disease A potential metabolic basis of disease progression" Severe NAFLD is characterized by oxidative stress, IR and progressive fibrosis, all of which can be modulated by DHEA. This particular study asked the question, "Can we, based on DHEA levels, differentiate patients with mild, moderate simple steatosis and NASH ; , and severe NAFLD NASH with fibrosis stage 3-4 ; ?" This is an impressive study. They had 78 patients with NAFLD and 44 controls. They do not go into detail about what these other diseases are, though in the results they say they compare NAFLD with cholestatic liver disease. I'm not sure that all 44 patients had cholestatic liver disease, which may be important because patients with cholestatic liver disease rarely have steatosis, and as far as we know, IR does not seem to play much of a role in this setting. Thus patients with cholestatic liver disease are reasonable controls. Serum levels of DHEA were obtained at the time of biopsy. Fifty-three had just simple steatosis and 25 had NASH. They were also interested in looking at fibrosis as well: stage 0-2 versus 3-4 with 3-4 being bridging fibrosis and cirrhosis ; . They found that overall patients with stage 3-4 were older. Patients with lower DHEA levels so DHEA being protective ; , have greater association of liver disease. They used a cut off level of 0.45 mcg dl, which appeared to separate patients with moderate to severe disease fibrosis stage 3-4 ; from those with mild disease. Again, they don't tell us how they got to this cut off is this a median level? It's not entirely clear. Every patient in the study who had stage 3 and stage 4 had DHEA level less than 0.45 mcg dl. If you look at the figure, there are several patients who had mild disease and also had low levels. So, it's not sensitive and it's not specific in that manner. However, if you had a higher level, it was very useful as a negative predictor. If you had high levels, you can confidently say, at least on this data, that you don't have severe disease. I think there is a typo in the abstract because they talk about greater than 0.45, I think it should be less than 0.45 and then everything makes sense. It's unclear what exactly the role of DHEA is but there's a lot of data in animal models supporting the fact that it improves IR as I mentioned. That's where most of the interest is. Insulin appears to be profibrogenic. When we talk about risk factors for steatosis, NASH, inflammation, fibrosis insulin seems to play a key role and anything which decreases IR may improve these conditions. When we talk about someone having IR, they tend to have high levels of insulin circulating throughout the day. For any given, because fluticasone.
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Of approximately $1, 328, 000. Cash used by our investing activities in 2004 were primarily related to cash used at merger of approximately $14, 875, 000, purchases of marketable securities of approximately $143, 037, 000, increases in restricted cash of approximately $13, 279, 000 and other assets of approximately $4, 238, 000 as well as purchases of property and equipment of approximately $1, 532, 000. These uses of cash were partially offset by proceeds from maturities of marketable securities of approximately $55, 824, 000 and sale of property and equipment of approximately $901, 000. Cash provided by our investing activities in 2003 was primarily due to proceeds from maturities of marketable securities and proceeds from sale of property and equipment. These sources of cash were partially offset by purchases of marketable securities, purchases of property and equipment as well as increases in other assets. Additionally, in 2003 the Company issued a bridge loan of approximately $6, 238, 000 to Genesoft in connection with the merger of the two companies in February 2004. Capital expenditures totaled approximately $1, 328, 000 and $1, 532, 000 in 2005 and 2004, respectively which primarily consisted of purchases of computer and related equipment to support the expanding sales force and, to a lesser degree, office furniture and leasehold improvements for the new office facilities. Capital expenditures in 2003 were approximately $121, 000 primarily consisting of purchases of computer-related equipment. Our financing activities provided cash of approximately $997, 000 in 2005, primarily due to proceeds from exercise of stock options of approximately $871, 000 and proceeds from the issuance of shares under the employee stock purchase plan of approximately $417, 000, offset by payments of long-term obligations of approximately $291, 000. Our financing activities provided cash of approximately $234, 391, 000 in 2004, primarily due to gross proceeds from the issuance of convertible notes of $152, 750, 000, net proceeds from issuance of stock through private placement in conjunction with the merger of approximately $80, 864, 000, proceeds from exercise of 2, 129, 865 stock options of approximately $1, 865, 000, and proceeds from exercise of warrants of approximately $195, 000 and proceeds from the issuance of 125, 542 shares of stock under the employee stock purchase plan of approximately $303, 000. These proceeds were partially offset by payments of long-term obligations of approximately $1, 586, 000. Our financing activities provided cash of approximately $1, 142, 000 in 2003 primarily from the net proceeds from the private placement of common stock of approximately $12, 650, 000, proceeds from issuance of stock under employee purchase plan and from exercise of stock options of approximately $952, 000 as well as the proceeds received from a legal claim with an investor of approximately $585, 000. These sources of cash in 2003 were partially offset by cash payment of $10, 000, 000 in connection with the redemption of the $15 million convertible notes, as well as payments on long-term obligations of approximately $3, 045, 000. At December 31, 2005, we had net operating loss carryforwards of approximately $377, 305, 000 and $278, 981, 000 available to reduce federal and state taxable income respectively, if any. In addition, we also had tax research credit carryforwards of approximately $20, 045, 000 to reduce federal and state income tax, if any. Net operating loss carryforwards are subject to review and possible adjustment by the Internal Revenue Service and may be limited in the event of certain cumulative changes in ownership interests of significant shareholders over a three-year period in excess of 50%. Additionally, certain of our losses have begun to expire due to time, not limitations. Our Outstanding Debt Obligations and Equity Financings -- In the quarter ended June 26, 2004, we issued $152, 750, 000 in principal amount of our 3.5% senior convertible promissory notes due April 2011. These notes are convertible into shares of our common stock at the option of the holders at a conversion price of $6.64 per share. We may not redeem the notes at our election before May 10, 2010. After this date, we can redeem all or a part of the notes for cash at a price equal to 100% of the principal amount of the notes to be redeemed plus accrued and unpaid interest. Upon the occurrence of a termination of trading of our common stock or a change of control transaction and carisoprodol.
July 19, 2003 FINANCIAL: Kurt reported the account balances for Wells Fargo $17.292.79 and Merrill Lynch $13, 294.98. A question was asked regarding the final accounting of the annual convention. There is still some outstanding income that needs to be compiled and may still be some outstanding expenses according to Pam Grant, committee chair. CSA AFFILIATION AGREEMENT: Jami and Becky reported about the AHIMA CSA Affiliation Agreement that was introduced to the BOD by Jami at last month's Transition Meeting. Each CSA has two and one-half years to implement conditions outlined in the agreement. AHIMA would prefer the CSAs sign the agreement by September 2003. Should a CSA fail to sign the agreement, they will no longer be eligible for dues rebates. Also of significance, CSAs that currently have "local" membership categories i. e. Courtesy Member ; will have to delete all references to "Member". AHIMA does not recognize individuals as members if they are not current with annual AHIMA dues. Motion was made and seconded to defer signature of the agreement until the August BOD meeting. Motion carried. LEADERSHIP UPDATE: Jami and Becky presented to the BOD a report on Summer Team Talks and the Leadership Conference held in Chicago this month. Jami presented to the Board a proposed amendment to the AHIMA Bylaws regarding increasing AHIMA dues, based on a cost of living index, without the approval of the House of Delegates. Also presented was a proposal addressing continuing education maintenance. This proposal outlines CE requirements and limits for HIM professionals holding multiple AHIMA approved credentials. The new proposal would cap the maximum # of units required at 50. The old CE schedule would require as many as 80 depending on the credential s ; . These issues will be presented to the attendees of regional coding roundtable meetings to be held in August. A schedule of the House of Delegates agenda was passed around to the board members. CODING ROUNDTABLE: Jami advised the board that several CSA Coding Roundtables, including Arizona received special recognition at the Coding Summit held in conjunction with the Leadership Conference. "Best Practices" were presented by several states. Jami did note that many CSAs have combined their Data Quality Committee with the Coding Roundtable. This may need to be re-explored by the BOD. An e-mail from Patience Hoag stated CSAs are being encouraged by AHIMA to have their Coding Roundtable Coordinators attend the National Convention Coding Community Meetings Saturday & Sunday prior to the convention. The BOD discussed the financial implication of this event on the association budget. Jami would like the BOD to discuss the possibility of combining committees at the next BOD meeting, as well as, possibly moving the DQ Spring meeting to the Fall and combing CR AHIMA Updates. ASSOCIATION MANAGEMENT: Donna provided an explanation of the purpose for exploring outsourcing additional resources to assist with the management of this association. She then introduced Bob & Linda Cherner of Silver & Cherner. Silver & Cherner provide management services to several organizations in the valley. Services provided include but are not limited to: Mailing & meeting registration, complete association management, web support, convention program management. Services provided on an "ala carte" basis. Special projects are priced on a per project basis not to exceed an agreed upon amount. Phone service is also available for a monthly fee. The board would like to obtain a proposal of association services as outlined by Donna and Kurt. August 16, 2003 NATIONAL CONVENTION: HIMA of AZ will support attendance of the Coding Roundtable Coordinator to the Coding Community meetings on Saturday & Sunday. FINANCIAL: Wells Fargo balance as of 7 $17, 259.71 and Merrill Lynch as of 7 $13, 339.10 ASSOCIATION MANAGEMENT: Kurt presented spreadsheet of Silver & Cherner's services. Several questions were raised regarding the services which need clarifying. Marcia felt a competitive bid would be in the association's best interest. Marcia will obtain an additional bid for association management services and Kurt will contact Silver & Cherner for clarification. CODING ROUNDTABLE UPDATE: Two AHIMA update meetings regarding House of Delegate HOD ; topics for the next convention have been held via the Coding Roundtables to date. Phoenix & Tucson attendees both were against the amendment to allow AHIMA to raise membership dues based on cost of living index without approval of AHIMA HOD. Both groups approved of the proposed minimum CE hour requirements. RELEASE OF INFORMATION FEES: Marcia addressed a concern that copy fees for subpoenas are not current and have not been revised for appx. 15 years since the statute went into effect. She also reported that a class action lawsuit in Tucson has set copy rates for only those facilities named in the suit. For copy service organizations there is no standard in Arizona. Members of the BOD question whether there is enough interest in the legislative community to pursue any lobbying activity by this association. Marcia offered to contact several different individuals to obtain feedback about the feasibility of possibly legislating Release of Information fees. CODING ROUNDTABLE DATA QUALITY COLLABORATION: Jami presented to the BOD information from the Summer Team Talks Leadership Conference Coding Summit, that some states have combined their Data Quality committees with the Coding Roundtable. Should HIMA of.
Eiceman, GA and Karpas, Z. Ion Mobility Spectrometry. 2005. Taylor and Francis Group. Boca Raton, FL 2 Parmeter, JE, and Eiceman, GA. Trace Detection of Narcotics Using a Preconcentrator Ion Mobility Spectrometer System. NIJ Report 602-00. April 2001. 3 Brand, D. Li, X, Wortley, T. Ion Trap Mobility Spectrometry Reducing Downtime in Cleaning Validation and Verification. Pharmamanufacturing . February 2006 4 Munden, R et al. IMS Limit Test Improves Cleaning Verification and Method Development. Pharmaceutical Technology Europe. October 2002 5 Peterson, DE, et al. Ion Mobility Spectrometry for Determination of Active Drug in Blinded Dosage Forms. AAPS. February 2005 pp18 - 19 6 FDA. Guide to Inspections of Validation of Cleaning Processes. July 1993 7 LeBlanc, D. Establishing Scientifically Justified Acceptance Criteria for Cleaning Validation of Finished Drug Products. Pharmaceutical Technology, Volume 22 10 ; . October 1998. 8 LeBlanc, DA. Setting Dose Limits Without Dosing Information. cleaningvalidation , Cleaning Memos, May 2001 9 Kramer, et al. Conversion Factors Estimating Indicative Chronic No-Observed-Adverse-Effect Levels from Short-Term Toxicity Data. Regulatory Toxicology and Pharemacology. Volume 23. pp249 255. 1996 10 Swartz, ME, Krull, IS. Analytical Method Development and Validation. 1997. Marcel Dekker, Inc. New York 11 Romano A, et al. Immediate hypersensitivity to cephalosporins. Allergy 57 ; Supplement 72. pp52-57. 2002 12 Rossi S Ed. ; 2004. Australian Medicines Handbook 2004. Adelaide, Australia. ISBN 0-9578521-4-2. 13 Cleaning limits provided in private communications and ceftin.
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That McAlindin's sense of isolation is not actionable. See Strother, 79 F.3d at 869 "Mere ostracism in the workplace is not enough to show an adverse employment decision. " citation omitted .12 In addition, the County's refusal to extend McAlindin's "right to return" beyond a year, which was dictated by its leave policy, was not an adverse employment action. Given that the County permitted McAlindin to return to his job and informally assured him all along that it would respect his rights under the ADA, we see no harm that constituted an adverse action. The remaining incidents, however, do qualify as adverse employment actions. We have previously rejected the County's argument that adverse actions must be severe."[A plaintiff] need not show that she was fired, demoted, or suffered some financial loss . Bouman v. Block , 940 F.2d 1211, 1229 9th Cir. 1991 ; . In Bouman, we held that if a transfer to a "position was not made available to [plaintiff] because of her involvement in protected activities, " then she suffered an adverse employment decision. Id. [18] Nonetheless, McAlindin's retaliation claim ultimately fails because he has not established the third element of a prima facie retaliation claim: that the adverse actions occurred because of his protected activities. See Strother, 79 F.3d at 868. The undisputed evidence shows that all of the adverse actions occurred because the County followed universallyapplied policies, and not because McAlindin was targeted for unfavorable treatment on account of his protected activities. We address each of McAlindin's retaliation claims below. McAlindin was not targeted for unfavorable treatment because of his protected activities; to the contrary, he was treated like all other employees. Although the ADA imposes a different standard by virtue of the duty to make reasonable accommodations, see supra, under FEHA, McAlindin must show that he was targeted for adverse treatment. McAlindin attempts to establish adverse treatment in four ways. First, McAlindin claims that the County denied him the opportunity to attend an off-site training seminar in the Natural computer language. The evidence indicates that the County expects its employees to learn Natural from a computer tutorial that they can use at work. The only other Systems Analyst learned Natural exclusively through the tutorial and on-the-job training. The County's expectation that McAlindin do the same is not evidence of retaliation. McAlindin's only response is that a County employee's statement that the County "has been able to rely almost exclusively on [the tutorial] and project assignments for our analysts to become proficient in Natural, " indicates that some analysts have received additional training. But even if that is the case, there is no evidence that the additional training included funding off-site seminars or that any such opportunities were distributed in a discriminatory manner. The possibility that some analyst may have attended a seminar at some point in time does not entitle McAlindin to do the same and celebrex.
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