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Poster Session P11. Clinical toxicology correlation between initial aminotransferases and PT values with severity of poisoning we evaluated biochemical changes in 12 pts with phalloid intoxications. Methods: We retrospectively evaluated medical histories of twelve patients with phalloid poisoning. Hospitaly treated in the Clinic of Toxicology and Urgent Internal Medicine last year. We compared the initial values of aminotransferases and PT in patients divided into two groups, according to the outcome. Four pts with lethal outcome 33.3% ; compared to the second group of 8 patients 66.6% ; whosurvived. Results: Increased levels of transaminases were noted after the second day, but highest values were detected approximately 5-th day. In the group with lethal outcome the average value of initial AST was 2052.75 1985366 ; , and of ALT was 1445.75 2773330 ; . In the second group the average initial value of AST was 327 22661 ; , and ALT was 801 222421 ; . Changes in PT were noted earlier and average initial values of PT was 56.5 35.590.2 ; sec. in the first group, and 18.425 10.835.5 ; in the second group. Conclusion: Aminotransferases and PT are important markers for clinical course of phalloid poisonings, but initial values of serum aminotransferases are not predictive as much as initial values of PT, which make it more useful prognostic parameter. 253 254 and chloroquine.
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M3 1. A CALORIMETRIC STUDY OF THE HYGROSCOPIC SETTING OF CALCINED GypSUM.-Joan A. Donnison, M. P. Chong, and A. R. Docking, Commonwealth Bureau of Dental Standards, Melbourne, Australia. Calorimetric studies on the setting of gypsum products were carried out chiefly to determine whether there was any increase in the rate of evolution of heat when a sample was allowed to set under hygroscopic conditions. It was found that the rate of evolution of heat was greater when Hydrocal set under water rather than under an inert liquid. It was also greater when extra water was added shortly after the commencement of mixing, the total amount of heat evolved at the end of the experiment, as well as the rate, being dependent on the amount of water added. By chemical analysis it was found that when sufficient water was added shortly after the commencement of mixing, any further addition of water did not effect more hydration. Also, the higher the water-powder ratio, the more water there was available and the smaller the effect of added water. The results indicated that hygroscopic setting is an extension of the setting process whereby hydration is completed to a greater degree. M3 2. A METHOD FOR EVALUATION OF THE EXPANSION OF CASTING INVESTMENT UNDER ACTUAL WORKING CONDITIONS.-George M. Hollenback, and John E. Rhoads independent dental research ; . It has long been felt that the measurement of the outside dimensions of test samples of casting investment is not necessarily a correct representation of what actually happens inside the mold cavity, either during the setting of the investment or during the subsequent mold-conditioning process. Because of this, it was felt that the possibility of actual mold measurement should be explored. Attempts to determine changes taking place in the mold cavity have been made by elaborate methods of measuring changes in the wax pattern itself which cannot give a true picture of changes in the mold wall ; and by the circuitous route of attempting to analyze dimensions of resultant castings made into the molds. Each of these methods, because an attempt is made to observe a primary change by means of a secondary result, may not show accurately the actual events taking place. A method of measuring has been developed whereby the dimensions of the mold cavity can be measured accurately during the period from initial set to final set of the investment. The method is simple, straightforward, and not subject to great experimental error. Results obtained using this equipment indicate that values considerably different from those previously established by currently used equipment do exist. Representative results.
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1. RockeyDC.Hepaticfibrosis, stellatecells, andportalhypertension. ClinLiverDis.2006; 10 3 ; : 45979. 2. Jackson J, Stein RA. Intensive statin therapy beneficial in heart emergenciesArch.InternalMed.2006; 25. 3. GoAS, LittleWC Ass2006; 1. 4. 99: TanA, LevreyH, DahmC, invitroandinvivo: AmJRespirCritCareMed1999; 159: 220227.
1. 2. 3. Katzenellenbogen, J. A., O'Malley, B. W. & Katzenellenbogen, B. S. 1996 ; Mol. Endocrinol. 10, 119131. Katzenellenbogen, J. A. & Katzenellenbogen, B. S. 1996 ; Chem. Biol. 3, 529536. Rosen, J., Day, A., Jones, T. K., Turner Jones, E. T., Nadzan, A. M. & Stein, R. B. 1995 ; J. Med. Chem. 38, 48554874. McDonnell, D. P., Clevenger, B., Dana, S., Santiso-Mere, D., Tzukerman, M. T. & Gleeson, M. A. G. 1993 ; J. Clin. Pharmacol. 33, 11651172. Berry M., Metzger, D. & Chambon, P. 1990 ; EMBO J. 9, 28112818. Tzukerman, M. T., Esty, A., Santiso-Mere, D., Danielian, P., Parker, M. G., Stein, R. B., Pike, J. W. & McDonnell, D. P. 1994 ; Mol. Endocrinol. 8, 2130. Webb, P., Lopez, G. N., Uht, R. M. & Kushner, P. J. 1995 ; Mol. Endocrinol. 9, 443456. Yang, N. N., Venugopalan, M., Hardikar, S. & Glasebrook, A. 1996 ; Science 273, 12221225. McDonnell, D. P., Clemm, D. L., Hermann, T., Goldman, M. E. & Pike, J. W. 1995 ; Mol. Endocrinol. 9, 659669. Beekman, J. M., Allan, G. F., Tsai, S. Y., Tsai, M.-J. & O'Malley, B. W. 1993 ; Mol. Endocrinol. 7, 12661274. Klinge, C. M., Traish, A. M., Driscoll, M. D., Hilf, R. & Bambara, R. A. 1996 ; Steroids 61, 278289. McDonnell, D. P., Dana, S. L., Hoener, P. A., Lieberman, B. A., Imhof, M. O. & Stein, R. B. 1995 ; Ann. N.Y. Acad. Sci. 761, 121137. Christman, J. K., Nehls, S., Polin, L. & Brooks, S. C. 1995 ; J. Steroid Biochem. Mol. Biol. 54, 201210. Grese, T. A., Sluka, J. P., Bryant, H. U., Cole, H. W., Kim, J. R., Magee, D. E., Rowley, E. R. & Sato, M. 1996 ; Bioorg. Med. Chem. Lett. 6, 903908. Kuiper, G. G. J. M., Enmark, E., Pelto-Huikko, M., Nilsson, S. & Gustafsson, J.-A. 1996 ; Proc. Natl. Acad. Sci. USA 93, 59255930. Mosselman, S., Polman, J. & Dijkema, R. 1996 ; FEBS Lett. 392, 4953. Grese, T. A. & Dodge, J. A. 1996 ; Annu. Rep. Med. Chem. 31, 181190, and references therein. Wakeling, A. E. & Bowler, J. 1988 ; J. Steroid Biochem. 31, 645653. Sato, M., Rippy, M. K. & Bryant, H. U. 1996 ; FASEB J. 10, 905912. Kedar, R. P., Bourne, T. H., Powles, T. J., Collins, W. P., Ashley, S. E., Cosgrove, D. O. & Campbell, S. 1994 ; Lancet 343, 13181321. Black, L. J., Sato, M., Rowley, E. R., Magee, D. E., Bekele, A., Williams, D. C., Cullinan, G. J., Bendele, R., Kauffman, R. F., Bensch, W. R., Frolik, C. A., Termine, J. D. & Bryant, H. U. 1994 ; J. Clin. Invest. 93, 6369. Draper, M. W., Flowers, D. E., Huster, W. J., Neild, J. A., Harper, K. D. & Arnaud, C. 1996 ; J. Bone Miner. Res. 11, 835842. Grese, T. A., Cho, S., Finley, D. R., Godfrey, A. G., Jones, C. D., Lugar, C. W., III, Martin, M. J., Matsumoto, K., Pennington, L. D., Winter, M. A., Adrian, M. D., Cole, H. W., Magee, D. E., Phillips, D. L., Rowley, E. R., Short, L. L., Glasebrook, A. L. & Bryant, H. U. 1997 ; J. Med. Chem. 40, 146167. Jones, C. D., Jevnikar, M. G., Pike, A. J., Peters, M. K., Black, L. J., Thompson, A. R., Falcone, J. F. & Clemens, J. A. 1984 ; J. Med. Chem. 27, 10571066. Dodge, J. A., Stocksdale, M. G., Fahey, K. J. & Jones, C. D. 1995 ; J. Org. Chem. 60, 739741. Crenshaw, R. R., Jeffries, A. T., Luke, G. M., Cheney, L. C. & Biaiy, G. 1971 ; J. Med. Chem. 14, 11851189. Grese, T. A., Cole, H. W., Magee, D. E., Phillips, D. L., Shetler, P. K., Short, L. L., Glasebrook, A. L. & Bryant, H. U. 1996 ; Bioorg. Med. Chem. Lett. 6, 26832686. Conley, R. A. & Heindel, N. D. 1975 ; J. Org. Chem. 40, 31693173. Dodge, J. A., Glasebrook, A. L., Magee, D. E., Phillips, D. L., Sato, M., Short, L. L. & Bryant, H. U. 1996 ; J. Steroid Biochem. Mol. Biol. 59, 155161. Sato, M., Kim, J., Short, L. L., Slemanda, C. W. & Bryant, H. U. 1995 ; J. Pharmacol. Exp. Ther. 272, 12521259. Palkowitz, A. D., Glasebrook, A. L., Thrasher, K. J., Hauser, K. L., Short, L. L., Phillips, D. L., Muehl, B. S., Sato, M., Shetler, P. K., Cullinan, G. J., Pell, T. R. & Bryant, H. U. 1997 ; J. Med. Chem. 40, 14071416. Stewart, J. P. 1990 ; Quantum Chemistry Program Exchange Indiana University, Bloomington, IN ; , Program No. 455, version 6.0 and references therein. Jordan, V. C., Collins, M. M., Rowsby, L. & Prestwich, G. 1977 ; J. Endocrinol. 75, 305316. Robertson, D. W., Katzenellenbogen, J. A., Hayes, J. R. & Katzenellenbogen, B. S. 1982 ; J. Med. Chem. 25, 167171 and references therein. Anstead, G. M., Carlson, K. E. & Katzenellenbogen, J. A. 1997 ; Steroids 62, 268303. McCague, R., Jarman, M., Leung, O. T., Foster, A. B., Leclercq, G. & Stoessel, S. 1988 ; J. Steroid Biochem. 31, 545548.
10 Baldwin DS. Depression and sexual dysfunction. British Medical Bulletin , 2001, 57: 81-99. Miller HB, Hunt JS. Female sexual dysfunction: review of the disorder and evidence for available.
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